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KMID : 0604520070330030181
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Journal of the Society of Cosmetic Scientists of Korea
2007 Volume.33 No. 3 p.181 ~ p.187
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The Inhibition of UVA-induced Matrix Metalloproteinase-1 in Human Dermal Fibroblasts and the Improvement of Skin Elasticity by Cirsium setidens Extract
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Sim Gwan-Sub
Kim Jin-Hwa
Lee Dong-Hwan
Lee Bum-Chun
Lee Geun-Soo
Pyo Hyeong-Bae
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Abstract
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In this study, we measured the anti-oxidative activity of Cirsium setidens and investigated its effect on UVA-induced MMP-1 expression in human dermal fibroblats. And then we examined possible improvement in skin elasticity by topical treatment with fomular including Cirsium setidens extract. The ethanol extract of C. setidens showed free anion radical scavenging effect(87.47 % at 1 mg/mL) and superoxide anion radical scavenging effect(61.71 % at 1 mg/mL) in the xanthine/xanthine oxidase system, respectively. At the concentration of 100 , C. setidens extract showed 95.54% inhibition on lipid peroxidation of linoleic acid. UVA-induced MMP-1 expression in human dermal fibroblasts was reduced to 54.69 % by treatment with 100 of C. setidens extract. A human clinical study, in which oil-in-water emulsion with C. setidens extract was topically applied, showed significant increase in skin elasticity. These results suggest that the C. setidens extract can be effective anti-aging ingredient for cosmetics applications.
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KEYWORD
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Cirsium setidens, antioxidation, MMPs, human dermal fibroblast, skin elasticity
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